Zimmer Issued Five New Patents for Subchondroplasty Joint Preservation Treatment

WARSAW, Ind., Feb. 27, 2014 /PRNewswire/ — Zimmer Holdings, Inc. (NYSE and SIX:
ZMH) today announced that the United States Patent and Trademark Office has
issued five new patents directed to the Subchondroplasty® Procedure, the
innovative new joint preservation procedure developed by Zimmer Knee Creations:
U.S. Patent No. 8,551,178, U.S. Patent No. 8,574,303, U.S. Patent No. 8,608,802,
U.S. Patent No. 8,617,166 and U.S. Patent No. 8,623,089. These patents broaden
the coverage of the first Subchondroplasty® Procedure patent issued, U.S. Patent
No. 8,062,364, to include new procedure methods, instrument kits, navigation
systems, implants and other anatomical sites.

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The novel Subchondroplasty® Procedure is a percutaneous outpatient intervention
that addresses the defects associated with subchondral bone marrow lesions
(BMLs). BMLs are related to stress fractures or micro-fractures, and are
currently diagnosed using MRI. Left untreated, these defects have been shown to
lead to cartilage degeneration, limited function, pain and greater risk for
joint deterioration.

“These valuable additions to our Subchondroplasty® Procedure patent portfolio
are the result of years of research and development,” said Michael Simpson, Vice
President and General Manager, Zimmer Knee Creations, Inc. “The
Subchondroplasty® Procedure is a differentiated clinical solution which
demonstrates Zimmer’s commitment to offering the most comprehensive range of
therapies for patients across the continuum of care.”

In this minimally invasive, arthroscopically-assisted procedure, navigation
instruments are used to inject specialized bone filler, without violating the
joint. As the bone filler is resorbed, it is replaced with new, healthy bone.
The Subchondroplasty® Procedure is the first procedure to treat bone-based
changes within a joint, and addresses an unmet clinical need between early
interventions, such as NSAIDs and joint arthroscopy, and total joint
replacement. Since its introduction in November 2010, more than 3,000
Subchondroplasty® Procedures have been completed.

About the Company
Founded in 1927 and headquartered in Warsaw, Indiana, Zimmer designs, develops,
manufactures and markets orthopaedic reconstructive, spinal and trauma devices,
dental implants, and related surgical products. Zimmer has operations in more
than 25 countries around the world and sells products in more than 100
countries. Zimmer’s 2013 sales were approximately $4.6 billion. The Company is
supported by the efforts of more than 9,000 employees worldwide. More
information about Zimmer is available at www.zimmer.com.

Logo: http://photos.prnewswire.com/prnh/20131216/MM33947LOGO

SOURCE Zimmer Holdings, Inc.

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